abstract：BACKGROUND:Increasing the rate of pathological complete remissions after neoadjuvant chemoradiation of rectal cancer has become a strategy to further improve the long-term oncological outcome of patients. This report evaluates the influence of preoperative intensified radiochemotherapy on the rate and outcome of surgic...

journal_title：International journal of colorectal disease

authors： Horisberger K,Hofheinz RD,Palma P,Volkert AK,Rothenhoefer S,Wenz F,Hochhaus A,Post S,Willeke F

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The incidence and risk factors of gastrointestinal diseases in pre-liver transplant population are still a matter of debate. In a retrospective analysis, we addressed two questions: (1) Are there any lesions that occur at a higher prevalence than in the general population, and (2) are there patient character...

journal_title：International journal of colorectal disease

authors： Gravante G,Delogu D,Venditti D

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND/AIMS:The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a predictor o...

journal_title：International journal of colorectal disease

authors： Kang MS,Park DI,Jeen YT,Keum B,Choi JH,Jung SA,Kim HS,Kim YH,Kim WH,Kim TI,Kim HJ,Yang SK,Myung SJ,Byeon JS,Lee MS,Jung IK,Chung MK,Choi H,Han DS,Song JS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Standard therapy for locally advanced rectal cancer (LARC) is concurrent neo-adjuvant chemo-radiation using infusional 5-fluorouracil (CIV-5-FU). Capecitabine (CAP) offers a convenient oral replacement for CIV-5-FU. There is no randomized trial comparing infusional 5-FU to capecitabine. We retrospectively co...

journal_title：International journal of colorectal disease

authors： Saif MW,Hashmi S,Zelterman D,Almhanna K,Kim R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The prognostic value of the degree of apoptosis in colorectal cancer is controversial. This study evaluates the putative clinical usefulness of measuring caspase-3 activity as a prognostic factor in colonic cancer patients receiving 5-fluoracil adjuvant chemotherapy. MATERIALS AND METHODS:We evalua...

journal_title：International journal of colorectal disease

authors： de Oca J,Azuara D,Sanchez-Santos R,Navarro M,Capella G,Moreno V,Sola A,Hotter G,Biondo S,Osorio A,Martí-Ragué J,Rafecas A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Neoadjuvant chemoradiation (nCRT) followed by curative surgery has gained acceptance as the therapy of choice in locally advanced rectal cancer. This prospective study evaluates the effect of nCRT on postoperative anorectal function and continence. PATIENTS AND METHODS:Group A consisted of 12 patie...

journal_title：International journal of colorectal disease

authors： Pietsch AP,Fietkau R,Klautke G,Foitzik T,Klar E

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Human phosphatases of regenerating liver (PRLs) can induce cell growth, differentiation, and malignant transformation. In this study, we used specific polyclonal antibodies against PRLs to investigate their expression in colonic adenocarcinomas and its correlation with patient gender, age, tumor differentiat...

journal_title：International journal of colorectal disease

authors： Wang Y,Li ZF,He J,Li YL,Zhu GB,Zhang LH,Li YL

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Ileal-pouch anal anastomosis has an established role in the treatment of ulcerative colitis. Controversy exists regarding the routine use of a diverting ileostomy. The aim of this study was to review the clinical and functional outcome of patients undergoing restorative proctocolectomy in the absence of a di...

journal_title：International journal of colorectal disease

authors： Davies M,Hawley PR

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:The aim of this prospective randomized clinical study was to evaluate the prevalence of ocular involvement in patients with inflammatory bowel disease (IBD). MATERIALS AND METHODS:We prospectively evaluated 116 patients who went to the gastroenterology clinic with endoscopically proven IBD between December 200...

journal_title：International journal of colorectal disease

authors： Yilmaz S,Aydemir E,Maden A,Unsal B

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND/AIM:Microscopic colitis is characterized by chronic diarrhea and specific microscopic changes in a macroscopically normal colonic mucosa. In this paper, we report the clinical and histological features of a group of Mexican patients with microscopic colitis. MATERIALS AND METHODS:Patients were identified fr...

journal_title：International journal of colorectal disease

authors： Rubio-Tapia A,Martínez-Salgado J,García-Leiva J,Martínez-Benítez B,Uribe M

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:For colorectal screening patients a mean gain of life time was previously calculated of about 30-50 days. Different recommendations for recognising at-risk groups and defining surveillance intervals after an initial finding of colorectal adenomas have been published. However, no benefit-risk analysis regardin...

journal_title：International journal of colorectal disease

authors： Becker F,Nusko G,Welke J,Hahn EG,Mansmann U

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:The prognostic impact of isolated lymphovascular invasion (LVI) after radical resection of rectal cancer is controversially discussed. However, it could be relevant to decide for an adjuvant treatment. AIM:The aim of the analysis was, based on the data of an observational study, to determine the prognostic ...

journal_title：International journal of colorectal disease

authors： Ptok H,Meyer F,Steinert R,Vieth M,Ridwelski K,Lippert H,Gastinger I,Study Group Colon\/Rectum Carcinoma (Primary Tumor Lesion).

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The transcription factor NF-kappaB is believed to play a key pathophysiological role in chronic intestinal inflammation. Further characterization of its mechanism of regulation, predominantly through cell signaling pathways, may provide clues as to the means of its intervention. One such potential signaling ...

journal_title：International journal of colorectal disease

authors： Parhar K,Morse J,Salh B

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIMS:As integral membrane proteins, claudins form tight junctions together with occludin. Several claudins were shown to be up-regulated in various cancer types. We performed an expression analysis of genes encoding tight junction proteins to display differential gene expression on RNA and protein level ...

journal_title：International journal of colorectal disease

authors： Gröne J,Weber B,Staub E,Heinze M,Klaman I,Pilarsky C,Hermann K,Castanos-Velez E,Röpcke S,Mann B,Rosenthal A,Buhr HJ

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:In situ ablation of colorectal liver metastases is frequently assessed for palliative treatment only. The establishment of clinically relevant lesion size and a lack of long-term survival data were regarded as main limitations to using them with curative intention. In contrast to surgical liver resection, ...

journal_title：International journal of colorectal disease

authors： Isbert C,Buhr HJ,Ritz JP,Hohenberger W,Germer CT

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIMS:We evaluated the incidence of dysplasia in the mucosectomy area using resected specimens to determine preoperative risk factors for the occurrence of dysplasia in this area. PATIENTS AND METHODS:We prospectively studied a consecutive series of 137 patients, each of whom underwent a restorative proc...

journal_title：International journal of colorectal disease

authors： Sagayama K,Ikeuchi H,Nishigami T,Nakano H,Uchino M,Nakamura M,Noda M,Yanagi H,Yamamura T

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Collagenous colitis is a chronic inflammatory bowel disease of unknown origin. In some cases of collagenous colitis, histomorphological features are comparable to other inflammatory bowel diseases. AIM:To assess functional NOD2/CARD15 polymorphisms for the susceptibility to collagenous colitis in a case-con...

journal_title：International journal of colorectal disease

authors： Madisch A,Hellmig S,Schreiber S,Bethke B,Stolte M,Miehlke S

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND AIM:Data on maximum resting pressure (MRP) and maximum squeeze pressure (MSP) changes after hemorrhoidectomy are not univocal and follow-up of patients undergoing surgery is mostly short-lived. The aim of this study was to prospectively examine during 1-year follow-up the long-term manometric results of ...

journal_title：International journal of colorectal disease

authors： Patti R,Almasio PL,Arcara M,Sparacello M,Termine S,Bonventre S,Di Vita G

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to dete...

journal_title：International journal of colorectal disease

authors： Spoettl T,Paetzel C,Herfarth H,Bencherif M,Schoelmerich J,Greinwald R,Gatto GJ,Rogler G

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The debate over sentinel lymph node mapping (SLNM) and focused pathologic examination to detect micrometastases in patients with colorectal cancer (CRC) continues. We present in this paper our experience with SLNM for CRCs to improve staging. In addition, we have detailed the mapping procedure on an anatomic...

journal_title：International journal of colorectal disease

authors： Yagci G,Unlu A,Kurt B,Can MF,Kaymakcioglu N,Cetiner S,Tufan T,Sen D

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND/AIMS:The advent of contrast-enhanced ultrasound (CEUS) has called into question the efficacy of standard ultrasonographic techniques. In this study, we evaluated B-mode and color-duplex imaging and CEUS in the detection of liver metastases, using intraoperative and histological findings as a reference. MATE...

journal_title：International journal of colorectal disease

authors： Konopke R,Kersting S,Bergert H,Bloomenthal A,Gastmeier J,Saeger HD,Bunk A

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:Recently, superficial elevated colorectal tumors have been increasingly diagnosed after improvements in endoscopic instruments and techniques. However, their biological characteristics remain obscure and it is difficult to predict malignant potential. The aim of this study is to clarify the characteristics...

journal_title：International journal of colorectal disease

authors： Nakahara T,Aoyama N,Maekawa S,Tamura T,Shirasaka D,Kuroda K,Nishioka C,Morita Y,Kasuga M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ulcerative colitis is an established risk factor for colorectal cancer but dysplasia reports are much more frequent than invasive neoplasm diagnosis. The effective activation of T lymphocytes that provide antitumor surveillance requires the presence of costimulation molecules such as CD80 and CD86 o...

journal_title：International journal of colorectal disease

authors： Scarpa M,Behboo R,Angriman I,Cecchetto A,D'Incà R,Termini B,Barollo M,Ruffolo C,Polese L,Sturniolo GC,D'Amico DF

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Restorative proctocolectomy with an ileal pouch-anal anastomosis is a surgical treatment of choice for ulcerative colitis and familial adenomatous polyposis (FAP). Pouchitis is a significant enigmatic morbidity. In the long-term, these patients, we anticipated, would experience biochemical profiling alterati...

journal_title：International journal of colorectal disease

authors： M'Koma AE

更新日期：2006-10-01 00:00:00

abstract：:Anal fissure is a common condition affecting young to middle-aged adults. It causes severe pain on defecation and rectal bleeding. The aetiology remains uncertain. Spasm of the internal anal sphincter is a constant feature. Nitric oxide (NO) is the major inhibitory neurotransmitter of the internal anal sphincter (IAS)...

journal_title：International journal of colorectal disease

authors： Lund JN

更新日期：2006-10-01 00:00:00

abstract：:In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and devel...

journal_title：International journal of colorectal disease

authors： German HNPCC Consortium.,Müller A,Beckmann C,Westphal G,Bocker Edmonston T,Friedrichs N,Dietmaier W,Brasch FE,Kloor M,Poremba C,Keller G,Aust DE,Fass J,Büttner R,Becker H,Rüschoff J

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:The treatment of acutely obstructed carcinoma of the left colon still represents a matter of controversy. The aim of the study was to evaluate the results of its management by emergency subtotal or total colectomy with immediate anastomosis without diversion. METHODS:An emergency subtotal/total colectomy was p...

journal_title：International journal of colorectal disease

authors： Hennekinne-Mucci S,Tuech JJ,Bréhant O,Lermite E,Bergamaschi R,Pessaux P,Arnaud JP

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to determine the detection rate of polyps using zoom chromoendoscopy (ZE) compared with standard video colonoscopy. PATIENTS AND METHODS:End-to-end colonoscopies were performed in 50 patients by two different endoscopists blinded for each other's results. Lesions detected ...

journal_title：International journal of colorectal disease

authors： Stergiou N,Frenz MB,Menke D,Riphaus A,Wehrmann T

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND AIM:Concurrent definitive treatment of underlying fistulas from infected anal glands at the time when the anorectal abscesses are drained is controversial as this is associated with a higher incidence of faecal incontinence, failure and recurrence. This meta-analysis was conducted to determine the merits...

journal_title：International journal of colorectal disease

authors： Quah HM,Tang CL,Eu KW,Chan SY,Samuel M

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The appearance of a carcinoma in the ileal pouch after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative proctocolitis is rare. Most of these adenocarcinomas previously described in literature develop from residual viable rectal mucosa. We report a case of an adenocarcinoma ...

journal_title：International journal of colorectal disease

authors： Knupper N,Straub E,Terpe HJ,Vestweber KH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies over the last 20 years have confirmed the safety and efficacy of strictureplasty in the treatment of obstructive Crohn's disease. However, almost all of these studies use strictureplasty to treat fibrotic strictures: limited resection being preferred to treat active disease stricture...

journal_title：International journal of colorectal disease

authors： Roy P,Kumar D

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:In colitis, iron therapy may be given to treat anemia, but it may also be detrimental based on our previous studies using a rat model with colitis where iron supplementation increased disease activity and oxidative stress. This effect was partially reduced by an antioxidant. AIMS:The aim of this study was t...

journal_title：International journal of colorectal disease

authors： Carrier JC,Aghdassi E,Jeejeebhoy K,Allard JP

更新日期：2006-05-01 00:00:00

abstract：:With the introduction of total mesorectal excision (TME) for treatment of rectal cancer, the prognosis of patients with rectal cancer is improved. With this better prognosis, there is a growing awareness about the quality of life of patients after rectal carcinoma. Laparoscopic total mesorectal excision (LTME) for rec...

journal_title：International journal of colorectal disease

authors： Breukink SO,Pierie JP,Hoff C,Wiggers T,Meijerink WJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:As angiogenesis is one of the key steps in tumor growth, invasion, and metastasis, antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. We investigated the cytotoxic, anti-adhesive, and anti-invasive effects of angiostatin in vitro and on intraperitoneal tumor growth in a ...

journal_title：International journal of colorectal disease

authors： Nestler G,Schulz HU,Tautenhahn J,Kuhn R,Krüger S,Lippert H,Pross M

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy. MATERIALS AND METHODS:Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer. RESULTS:The IGF system...

journal_title：International journal of colorectal disease

authors： Davies M,Gupta S,Goldspink G,Winslet M

更新日期：2006-04-01 00:00:00

abstract：AIMS:This study assesses the value of endorectal ultrasound (ERUS)-directed biopsy in detecting local recurrence of rectal cancer. METHODS:We reviewed the records of patients undergoing ERUS by a single surgeon for surveillance after treatment of rectal adenocarcinoma. Lesions suggestive of local recurrence underwent ...

journal_title：International journal of colorectal disease

authors： Morken JJ,Baxter NN,Madoff RD,Finne CO 3rd

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Despite the excellent results published on circular stapled mucosectomy (CSM), there is still some concern about the application of PPH-33 in the advanced haemorrhoidal disease, where a major prolapse may lead to insufficient resection and ensuing early recurrence. This study is aimed at comparing t...

journal_title：International journal of colorectal disease

authors： Pérez-Vicente F,Arroyo A,Serrano P,Candela F,Sánchez A,Calpena R

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The ileal pouch-anal anastomosis (IPAA) has become a standard procedure for patients with ulcerative colitis requiring surgical intervention. The technique has greatly improved and, since 1990, all patients at Huddinge University Hospital have been operated on with the double stapled technique. Pelvic seps...

journal_title：International journal of colorectal disease

authors： Hallberg H,Ståhlberg D,Akerlund JE

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Inpatients developing upper gastrointestinal (GI) haemorrhage are at increased risk of death. This study was performed to elucidate differences in inpatients and outpatients. PATIENTS/METHODS:Three hundred and sixty-two patients who needed esophagogastroduodenoscopy for upper GI bleeding were ident...

journal_title：International journal of colorectal disease

authors： Klebl FH,Bregenzer N,Schöfer L,Tamme W,Langgartner J,Schölmerich J,Messmann H

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Although the technique for the surgical repair of rectal prolapse has advanced over the years, no ideal procedure has been found. We aim to test a new surgical procedure for abdominal rectopexy that uses the greater omentum to support the rectum below the rectopexy, to reconstruct the anorectal angle and dispen...

journal_title：International journal of colorectal disease

authors： Di Giorgio A,Biacchi D,Sibio S,Accarpio F,Sinibaldi G,Petrella L,Cappiello FR,Sammartino P

更新日期：2005-03-01 00:00:00